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Pyridoxine (Vitamin B6) - Vitamin B6 is involved int he process of making serotonin and norepinephrine, as well as the formation of myelin

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44–47 On the basis of all these results, EULAR guidelines state that bosentan should be considered for reduction in the number of new DUs in SSc, especially in patients with multiple DUs despite the use of calcium-channel blockers (CCBs), PDE5 inhibitors, or iloprost therapy (strength of recommendation: A)

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