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Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased

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However, the weight loss achieved with a 0.5 mg dose (9.2%) was only slightly lower than that of a 1 mg dose (10.6%)