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The multiple phosphate-binding interactions to a common surface along NBD1 and the Lasso motif explain the well-known robustness to loss of any single phosphorylation site on the R-domain 9,11 and the requirement for an intact N-terminus containing the Lasso motif of CFTR for activity 33

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3.1 Gene regulation method MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression and are implicated in various diseases