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H2 blockers can lower vitamin B12 concentrations in the body by impairing how pepsin in the body works, which is necessary for efficient B12 absorption

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For instance, one study notes that people with excess weight or obesity appear to have lower vitamin B12 levels than people who have a body mass index (BMI) in the “normal” range ( Additional research has observed that people who voluntarily took vitamin B12 supplements gained between 2.5–17 fewer pounds (1.2–7.7 kg) over 10 years than those who did not supplement with this vitamin ( Still, such observational studies cannot confirm whether low vitamin B12 levels are what caused the weight gain, nor whether they’re what protected against low levels