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Dihexa is reported to be active at picomolar concentrations in synaptogenesis assays—approximately 10,000–10,000,000-fold more potent than BDNF (brain-derived neurotrophic factor) in some in vitro measures, though this comparison involves different assay conditions and should not be taken as a direct clinical equivalence claim

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780 , 781 Concerns remain, however, about the “digital divide” facing caregivers who do not have reliable broadband access or do not regularly use the internet