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Cagrilintide, Tirzepatide, and Retatrutide Peptides: Comparing Metabolic Mechanisms

Whereas the TMPRSS2-PAR2 pathway is a predominant homeostatic driver of GIP in physiological conditions, in obesity TMPRSS2 deletion fails to reduce GIP and, presumably, GIP-dependent weight gain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Lauder A., Chen C., Bolson R.M., Leversedge F.J