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The next trial commenced immediately following the rest period
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As mentioned earlier eosinophils are equipped with ability to interact with the ECM via expression of specific integrins (CD11c, CD11b, α5 integrins) and their presence during pathological inflammation (EoE, transplantation, allergy) is often associated with fibrosis 1 Under conditions of allergic inflammation airway eosinophils exhibit a hyper adhesive phenotype towards a provisional ‘immature’ matrix that is deposited following tissue injury 98 and their presence promotes collagen deposition and increased airway smooth muscle
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