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The literature search identified 31 lifespan studies Our search (see Table S1 for the PRISMA 2020 checklist and Table S2 for the search strategies) has identified a total of 1471 studies (see supplemental file) and, after screening the titles and abstracts, 495 (33.7%) cancer studies, 383 (26.0%) human studies, 184 (12.5%) cell studies, 164 (11.1%) plant studies, and 17 (1.2%) studies in other organisms were excluded