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Frontiers | Nutritional insights into pulmonary fibrosis: a comprehensive review on the impact of vitamins
The authors emphasize the necessity of testing such combinatorial interventions in naturally aged rodents to better capture the complexity of late-life aging phenotypes, as opposed to relying solely on progeroid or accelerated models, since interventions tested in such models are at risk of disproportionately addressing a single cause of aging phenotype (Lewis and de Grey, 2024)
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Moreover, (iii) free 3-amino hydrogens were important for tyrosinase inhibition but not for the melanogenesis inhibition on B16 cells, 1,3-disubsituted derivatives showed greater potency in melanogenesis inhibition ( 24f )
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