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Interestingly, FGF-2 level persisted to be elevated until 12 weeks of cuprizone exposure, failing to potentiate proliferation of OPC significantly, since both the wt mice and FGF −/− mice displayed a similar number of OPC (Armstrong et al., 2006), suggesting that FGF-2 may not be an essential/exclusive mitogenic factor for OPC in vivo , and may even predominantly promote an inhibitory effect impeding OPC differentiation and remyelination (Armstrong et al., 2006)