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However, the high viscosity of the collagen solution and the protein adsorption properties of collagen can easily lead to membrane pore clogging, which imposes high requirements on the surface treatment and cleaning processes of the membrane components

Mibelle Biochemistry

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Indeed, a recent proposal suggests that in conditions where iron is proposed to be pathogenic, iron-induced liver damage may in fact be potentiated by coexistent inflammation, with subsequent necrosis and hepatic stellate cell activation driving fibrosis [85]