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While the emphasis is placed on Mediterranean species, non-Mediterranean jellyfish, as Nemopilema nomurai (Kishinouye, 1922), Rhopilema esculentum (Kishinouye, 1891) are also considered when relevant in this review, exclusively for comparative purposes, as widely studied reference species in jellyfish biochemistry in order to provide broader insights and to identify bioactive compounds conserved across different biogeographical regions ( 1.4 Objectives and novelty of the study This review aims to provide a comprehensive synthesis of current advances in extraction methodologies, molecular and supramolecular characterization, and the expanding range of biomedical applications of jellyfish-derived compounds, with particular emphasis on species occurring in the Mediterranean Sea

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