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Pharmacokinetically, curcumin’s limited oral bioavailability due to poor solubility and extensive hepatic metabolism has prompted the development of enhanced formulations, including liposomal, nanoparticle, and piperine-adjuvanted forms, all of which demonstrate greater systemic absorption and target tissue delivery

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However, we note from inspection of the human genome that alternative splicing could theoretically generate a 94 amino addition at the N-terminus that contains a mitochondrial-targeting sequence