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Large-scale randomized clinical trials are essential to develop standardized treatment protocols and validate long-term efficacy and safety before peptides can be routinely advocated for chronic rotator cuff tendinopathy management [53,54,58]

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In summary, the results of this study indicate the novelty of vanillic acid therapeutic impact on different behavioral, molecular, biochemical, and histological tests conducted on a cuprizone mouse-model of multiple sclerosis