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Mistake 1: adding water too fast Squirting bacteriostatic water directly onto the lyophilized powder creates foam and mechanical stress that can denature the peptide

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Santa Maria et al., 2014), thus supporting the idea that a fully mutated FMR1 transcript can have toxic effects and that elongated transcripts are causative for FXTAS, but not for FXS, although some mRNA is present in many FXS patients (Tassone et al., 2001)