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Increased levels of LPO products were observed also in serum/plasma from AD subjects, supporting their use as biomarker for disease diagnosis, prognosis, and therapy (294, 295)
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For example, the pi and mu classes of GSTs modulate the mitogen-activated protein kinase (MAPK) signaling pathway responsible for stress response, cell proliferation, and apoptosis via direct interactions with c-Jun N-terminal kinase 1 (JNK1) and apoptosis signal-regulating kinase (ASK1) [8,9]
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