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Despite promising data in vitro , however, further development of CC0651 has largely failed due to difficulties in optimization ( The UBE2N-UBE2V1 heterodimer is an E2 enzyme that catalyzes the synthesis of K63-specific poly-ubiquitin chains

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Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice