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It has been shown that IFN-γ is a key player in xanthine oxidase (XO)-mediated oxidative stress
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In contrast, GSH cannot be regenerated in Gsr −/− neutrophils and upon depletion of GSH, ROS leaked out from the phagolysosomes will remain unopposed in reacting with the cellular organelles and enzymes, including those responsible for the generation of NADPH from glucose
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