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In colorectal cancer, N-glycosylation of CTSD by DDOST and STT3B suppresses ferroptosis by regulating ACSL4 and SLC7A11, facilitating liver metastasis ( 3 The role of ferroptosis in tumor microenvironment 3.1 Overview of ferroptosis in tumor microenvironment Ferroptotic cancer cells exert dual roles within the TME by releasing a variety of signals, which can both activate antitumor immune responses and promote the formation of an immunosuppressive TME