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Funding This work was supported in part by grants from National Natural Science Foundation of China (82070442, 82370435), Program of Chongqing Medical University for Youth Innovation in Future Medicine (W0085), Project of Chongqing Medical Talent Studio (2022), Natural Science Foundation Project of Chongqing (2023NSCQ-MSX1358), Key Program of The Third Affiliated Hospital of Chongqing Medical University (KY22037), and the National Institutes of Health (P01HL074940, DK039308, DK119652, and DK134574)

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The limited representation of Level 4 evidence, confined to a single systematic review of fractures, accentuates the depth of the findings while simultaneously highlighting domains warranting further high-level research to corroborate assertions across diverse medical contexts