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This unique feature of Zn II metalloenzymes has motivated the deployment of de novo protein design to create highly efficient novel Zn II catalysts in a diversity of biomolecular scaffolds 102,103 in a way that extends far beyond zinc metalloenzymes themselves

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Achieving this goal will not only generate novel therapies for persistent diseases such as tuberculosis, drug-resistant malaria, and visceral leishmaniasis, but will also create a flexible platform adaptable to future pandemic threats