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The reactions between Cr(VI) and biological reductants like thiols and ascorbate result in the production of reactive oxygen species such as superoxide ion, hydrogen peroxide, and hydroxyl radical, ultimately leading to oxidative stress in the cell causing damage to DNA and proteins (Stohs & Bagchi, 1995)

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Mutations in the AIRE gene cause autoimmune polyendocrinopathy, a condition where multiple organs come under immune attack simultaneously