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Firstly, excessive accumulation of ROS within mesangial cells under chronic hyperglycemia can lead to cell death by activating mTOR, 66 sirtuin1, 67 and XBP1, 60 resulting in renal dysfunction
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A main mechanism of its detoxification is the GSH conjugation, forming the glutathionyl–hydroxynonenal adduct, which is a cyclic hemiacetal [171]
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