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It will then systematically discuss the upstream regulatory mechanisms of GPX4 in the context of OA, including the System Xc − and nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathways, as well as its downstream biological effects, such as impacts on chondrocyte survival, inflammatory responses, and ECM metabolism

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Ebizuka H., Ihara M., Arita M