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At that point, on the fourth post-injury day, the additional practical significance of BPC 157 therapy was demonstrated as the therapy was given continuously per orally in drinking water to the rats who already had an advanced spinal cord injury, until the rats were sacrificed on day 30 after injury
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As for the more general TKIs the sequence homology between IGF-1R and IR-A/B kinase domains presented a major problem and therefore side effects were of great concern ( The IGF-signalling system has long been an area of therapeutic interest in the treatment of breast cancer which was further supported by the findings of both the European Prospective Investigation into Cancer and Nutrition (Kaaks et al., 2014) and the Endogenous Hormones and Breast Cancer Collaborative group (Murphy et al., 2020)
