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Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Subcutaneous Protocol (4 mL = 12.5 mg/mL) Frequency: Inject once or twice daily subcutaneously

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Key Features: 3-4 injection series (weekly administration) 30mg per 2mL dose Moderate molecular weight Rheological properties similar to healthy synovial fluid [5] Clinical Performance : When compared to healthy knee parameter values, Orthovisc (along with Euflexxa) was typically most similar to healthy knee synovial fluid [5][7]

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