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Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease

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Although these findings do not completely exclude the effect on kidney parenchymal cells or off-target effects, these results suggest that sulfasalazine prevents the formation of TLS not by attenuating tubular injury but via its inhibitory effect on of the cystine/glutamate transporter specifically expressed within TLS