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Mechanistically, Saracatinib inhibits TGF-β-induced Smad3 phosphorylation, thereby suppressing key fibrotic markers—such as α-SMA, type I collagen, and plasminogen activator inhibitor-1 (PAI-1)—in human lung fibroblasts, while reversing EMT-related pathways (Ahangari et al., 2022)
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