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In mammalian liver, the methylation of arsenic to MMA and DMA occurs at a high level by an incompletely characterized methyltransferase (Figure 3) using S-adenosylmethionine (SAM) as a methyl donor
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Warburg noticed that, unlike normal cells, most cancer cells produce energy not predominantly through the citric acid cycle and oxidative phosphorylation (OXPHOS) in the mitochondria but through glycolysis followed by lactic acid fermentation in the cytosol (this phenomenon is known as the ‘Warburg effect’) [5]
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