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It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase [17] [18] (GARFT)

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Meanwhile, signs of postural instability, gait dysfunction, speech difficulties and cognitive impairment manifest in the late stage of the disease [319, 320]