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95% CI, 0.72–0.90, p 99 kg) and older age (45–84 yrs)
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Notably, when co-cultured with recombinant human PD-L1, PD-1-positive CD71+ red lineage progenitor cells and PD-1-positive CD34+ hematopoietic stem progenitor cells (HSPCs) activate caspase-3 in myelodysplastic syndromes (MDS)-pre-AML lesions, resulting in apoptosis and ineffective hematopoiesis ( The main manifestations of PD-1-mediated immunosuppressive effects were high Treg activation, upregulation of CTLA-4 expression, and enhancement of immunosuppressive functions
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