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447 Moreover, these agents promote hemodynamic equilibrium, 18 diminish thrombotic propensity, 448 alleviate endothelial oxidative stress, 449 attenuate inflammatory processes, 450 and foster a favorable balance of the gut microbiota, 451 all of which collectively contribute to the salutary effects of these agents in patients with AS

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Better specificity comes from refining motif sequences that match receptors on granulosa cells, endometrial stromal cells, or Leydig cells, reducing action on other organs