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p 7% mortality, overt clinical signs of toxicity or significantly reduced body-weight gain (Seidenberg et al., 1986

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In HD, this phenotypic shift involves cyclic GMP-AMP synthase (cGAS)-stimulator of interferon response cGAMP interactor (STING) pathway activation: Mutant Huntingtin (mHTT) induces mtDNA leakage, triggering chronic neuroinflammation via type I interferon responses (52-54)