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Within the nucleus, NRF2 binds to promoter regions of target genes which contain antioxidant response element (ARE) sequences, ultimately inducing the transcription of cytoprotective genes, i.e., those encoding for phase II detoxification enzymes and antioxidants
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It appears as larger patches of discoloration, typically on the cheeks, forehead, and upper lip, and is strongly linked to hormonal changes and UV exposure
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