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Microbiome differences were greater between the two groups switched from WD to LD (i.e., WD/LD-V and WD/LD-T) and the two diet control groups (i.e., LD/LD-V and WD/WD-V) compared to the microbiome differences observed between the lean (LD/LD-V) and obese (WD/WD-V) control groups

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For many of these extracellular stimuli there are multiple different GPCRs, meaning that the same extracellular signal might give rise to different intracellular responses depending on which receptor subtype it encounters