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Direct in vitro comparisons of these mAbs showed comparable antibody-dependent cell-mediated toxicity (ADCC) and binding affinities, but remarkable differences in the ability to induce direct apoptosis, to induce complement-mediated cytotoxicity (CDC), to inhibit enzymatic activities, and to induce antibody-dependent cell-mediated phagocytosis (ADCP)(Figure 2 and Table 12)[41-42]

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Administered subcutaneously, its injectable form is rapidly absorbed and distributed to metabolically active tissues, where it specifically binds and inhibits NNMT catalytic activity without interfering with other enzymes in the nicotinamide pathway or NAD+ synthesis