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Several studies highlighted that those faecal miRNAs are promising biomarkers for the screening and diagnosis of CRC, as the faecal matter comes into close contact with the intestinal lumen and may contain cells exfoliated from malignant colonocytes (184)
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Therefore, the present findings should be interpreted as providing mechanistic insight into conserved processes rather than direct clinical prediction, and further validation in complementary models and human studies is warranted
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