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The 2024 pharmacokinetic work adds one relevant observation — the compound undergoes heavy first-pass hepatic metabolism in mice — which is the kind of property that tends to matter for interactions, though no study has examined which enzymes are involved or what else they handle

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By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, allowing more substrate to enter the NAD+ salvage pathway