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Our structures reveal a location-conserved yet charge-distinct pocket discriminating the effects of ligand PTM states on receptor subtype preference, the unique pocket topology underlying selectivity of SR146131 and gastrin-17, the conformational changes in receptor activation, and key residues contributing to G protein subtype specificity, providing multiple structural templates for drug design targeting the brain–gut axis

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Safety, side effects, and who may not be a candidate Possible IV-related problems include pain, bruising, bleeding, failed placement, infiltration, vein irritation, infection, allergic reaction, medication side effects, electrolyte disturbances, and fluid overload