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These substances imitate natural hormones or interfere with how the body controls hormones, which can disrupt the body’s normal balance.4 Insulin resistance : Insulin resistance can cause elevated estrogen levels in young women by boosting the activity of aromatase, an enzyme responsible for producing estrogen

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NNMT is overexpressed in several tumor types including gastric and thyroid cancers, and inhibiting it has been proposed as anti-tumor in those contexts