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In the inactive resting Gαβγ complex, the Gα subunit is bound to the guanine nucleotide, guanosine diphosphate (GDP), but when a GPCR is activated, the receptor can catalyze a ”nucleotide exchange” reaction” on the Gα subunit (Figure 2)

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10.1093/hmg/ddr501 114 GuyJ.ChevalH.SelfridgeJ.BirdA