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The antinociception of KAE tested at an ED 80 oral dose (45 mg/kg in C57BL/6J and 100 mg/kg in 129Sv6 mice) and was lost in MOR KO mice, while antinociception remained intact in delta opioid receptor (DOR) and kappa opioid receptor (KOR) KO mice in both C57BL/6J and 129Sv6 strains (Figure 2E and S2E, respectively)

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Wright, Esq