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The efficacy of this mechanism would be dependent on off-and-on rates of the associated proteins, their ability to compete with G protein complexes, and the overall conformational modulation of the receptor-ligand binding site
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Substrate specificity profiling of natural and evolved proteases To assess the substrate preferences of a protease in a broad and rapid manner, we developed a method for profiling protease activity on a substrate library by adapting the PACE selection circuit
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