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The arterial endothelial cells uniquely expressed Alpl and Hey1 , the capillary endothelial cells strongly expressed Lpl , and the venous endothelial cells expressed Vwf , Hif1a , Icam1 , Lrg1 and Aplnr (Extended Data Fig
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Patients without confirmed deficiency but with risk factors may benefit from prophylactic oral B12 supplementation (typically 50–150 micrograms daily), though this should be discussed with their healthcare provider rather than self-initiated
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