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Additional information The present work was supported by U.S

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Another study in rats on the same HFD plus 0.25 g LA/100 g body weight demonstrated that SIRT1 and SIRT3 enhanced LA's antioxidant defense by deacetylating Foxo3a and PGC1β, thereby reducing oxidative damage of mitochondrial DNA, restoring oxidative balance, and resisting oxidative stress