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APOE3 muscle in males and females, contribute to energy metabolism by providing α-ketoglutarate to the citric acid cycle or by participating in electron transfer to cytochrome c, respectively (Isabelle Papet et al., APOE4 upregulates protein expression in young mice in a pattern that would likely support energy metabolism is consistent with a study from Perkins et al., which demonstrated increased levels of proteins involved in glucose transport and oxidative phosphorylation in the posterior cingulate brain region of young adult APOE4 carriers compared to non-carriers (Perkins et al., APOE4 in females and decreased by APOE4 in males, reflecting a sex-divergent response to APOE4 in the regulation of the same mitochondrial protein