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In 2023, a study by the American Medical Association found that improper coding and documentation of therapeutic injections resulted in over $500 million in denied claims for healthcare providers

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Meanwhile, the degradation processing of p100 not only forms p52 but also allows the nuclear translocation of the noncanonical NF-κB complex p52/RelB and then activates the NF-κB (Senftleben et al., 2001