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EW systems cannot be validated properly only in clean laboratory conditions or polite demonstrations where nothing important is trying to deceive them

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65,69 A number of groups have attempted to simply mitigate the unexplainable underprediction issue by employing a regression-based “fudge” factor to their data, 69–72 and such approaches are common in lead optimization as a practical approach to predict clearance (or rank-order compounds by CL int ) despite the unpredictability of IVIVE