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High-pressure (e.g., greater than 80 to 100 cm H 2 0), long-duration (e.g., greater than 10 minutes) hydrodistension is associated with increased frequency of serious AEs (e.g., bladder rupture, sepsis) without a consistent increase in benefit

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In September, Pfizer offered to buy Metsera for $4.9 billion, but less than a month later, Novo Nordisk made an unsolicited bid of $6.0 billion in cash