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They improve the hydrosolubility of nutraceuticals, control their release in the GIT, prolong the residence time in the GIT, and improve intestinal permeation and transcellular delivery [154]

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This figure highlights the convergence of multiple TCM interventions on the Keap1/Nrf2/ARE axis, GPX4, SLC7A11, ACSL4, and iron transporters, illustrating the multi-target nature of TCM and guiding future combination strategies